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UrduScientists report a method for stable attachment of peptides to tRNAs, which has allowed them to gain new fundamental insights into ribosome function by determining the atomic-level structures of ribosomes and the shapes that peptides take inside the ribosome.
Tag: Ribosome
New ribosome-targeting antibiotic acts against drug-resistant bacteria
A new study published in Nature reports on the molecular mechanism that allows a new antibiotic drug to overcome resistance.
Can antibiotics treat human diseases in addition to bacterial infections?
A new Nature Communications study shows that eukaryotic ribosomes can be modified to respond to antibiotics in the same way that prokaryotic ribosomes do.
Unlocking ‘the shape of water’ in mechanisms of antibiotic resistance
Researchers captured and comparted hi-res images of ribosome structures from sensitive and resistant bacteria and report that a water molecule needed for antibiotic binding was not present in the ribosomes from the drug-resistant bugs.
Seeking to avoid ‘full lockdown,’ cells monitor ribosome collisions
But sometimes ribosomes get stuck or stall on roadblocks along defective mRNA molecules. New research from Washington University in St. Louis shows that cells monitor for ribosome collisions to determine the severity of the problem and how best to respond when things start to go awry.
Self-Assembling Ribosome Could Lead to Novel Vaccines
The Weizmann Institute’s Prof. Roy Bar-Ziv has demonstrated the self-synthesis and self-assembly of a ribosomal subunit on the surface of a chip. The breakthrough could lead to novel types of vaccines, including for antibiotic-resistant bacteria, or to assembly lines to produce complex molecules for a range of industries.
Mapping the pathway to gut health in HIV patients
A UC Davis study found that Lactobacillus plantarum bacteria rapidly repaired damaged gut lining (known as leaky gut) in monkeys infected with chronic simian immunodeficiency virus (SIV), an HIV-like virus. It linked chronically inflamed leaky gut to the loss of PPARα signaling and damage to mitochondria.
Scientists Discover New Antibiotic in Tropical Forest
Scientists from Rutgers University and around the world have discovered an antibiotic produced by a soil bacterium from a Mexican tropical forest that may help lead to a “plant probiotic,” more robust plants and other antibiotics. Probiotics, which provide friendlier bacteria and health benefits for humans, can also be beneficial to plants, keeping them healthy and more robust. The new antibiotic, known as phazolicin, prevents harmful bacteria from getting into the root systems of bean plants, according to a Rutgers co-authored study in the journal Nature Communications.