English
Arabic
Chinese (Simplified)
Dutch
Esperanto
French
German
Greek
Italian
Japanese
Korean
Portuguese
Russian
Spanish
UrduResearchers at the UNC School of Medicine have found that a metabolic enzyme called Acetyl-CoA Carboxylase causes T cells to store fat when they are in solid tumors, rather than burning fat for energy.
Tag: Cell Physiology
How bacteria surf cargo through the cell
The University of Michigan researchers found some bacteria ship cellular cargo by “surfing” along proteins called ParA/MinD ATPases
Food Temperature Linked to Taste Bud Nerve Activity
Article title: Effects of temperature on action potentials and ion conductances in type II taste-bud cells Authors: Zhongming Ma, Usha Paudel, J. Kevin Foskett From the authors: “Here we show that the electrical activity of type II taste-bud cells that…
Bicarbonate Promotes Potassium Chloride Cotransporter Expression in Kidney Cells
Article title: Bicarbonate is the primary inducer of KCC3a expression in renal cortical B-type intercalated cells Authors: Mohammed Z. Ferdaus, Andrew S. Terker, Rainelli Koumangoye, Susan M. Wall, Eric Delpire From the authors: “KCC3a expression is stimulated in alkalemia. This…
Researchers ID Protein as Mitochondrial Homeostasis Regulator
Article title: A20 binding and inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1)—a novel modulator of mitochondrial autophagy Authors: Rosetta Merline, Heiko Rödig, Jinyang Zeng-Brouwers, Chiara Poluzzi, Georg Tascher, Jonas Michaelis, Jaime Lopez-Mosqueda, Andrew Rhiner, Lisa Sophie Huber, Valentina Diehl,…
Researchers Explore Additional Pathways that May Contribute to Aneurysm Formation
Article title: Ecto-5′-nucleotidase (Nt5e/CD73)-mediated adenosine signaling attenuates TGFβ-2 induced elastin and cellular contraction Authors: Rolando A. Cuevas, Ryan Wong, Pouya Joolharzadeh, William J. Moorhead III, Claire C. Chu, Jack Callahan IV, Alex Crane, Camille K. Boufford, Angelina M. Parise, Aneesha…
Researchers ID Gene and Protein Involved in Muscle Wasting, Could Lead to Targeted Treatment
Article title: Pathophysiological levels of GDF11 activate Smad2/Smad3 signaling and induce muscle atrophy in human iPSC-derived myocytes Authors: Mikako Honda, Takumi Makino, Xiaolin Zhao, Mariko Matsuto, Hidetoshi Sakurai, Yu Takahashi, Makoto Shimizu, Ryuichiro Sato, Yoshio Yamauchi From the authors: “In…
Researchers Explore Role of Plasma Membrane Pump in Calcium Signaling
Rockville, Md. (September 1, 2022)—Research published ahead of print in the journal Function suggests the plasma membrane Ca2+ ATPase (PMCA) pump helps regulate cytosolic calcium signaling. Cytosolic calcium is found within the cells’ intracellular fluid—the cytosol is one such liquid—and…
Selective Autophagy Process Protects Heart Muscle Cells from Death
Article title: Chaperone-mediated autophagy protects cardiomyocytes against hypoxic cell death Authors: Rajeshwary Ghosh, Jennifer Jason Gillaspie, Kenneth S. Campbell, J. David Symons, Sihem Boudina, James Scott Pattison From the authors: “In summary, the present study demonstrated the importance of [chaperone-mediated…
Study Analyzes Functional Properties of Volume-regulated Anion Channels
Article title: LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology Authors: Toshiki Yamada, Eric E. Figueroa, Jerod S. Denton, Kevin Strange From the authors: “We propose that homohexameric [leucine-rich repeat containing 8] chimeric channels provide unique opportunities for generating…
Study Explores Changes in Liver Cancer Cell Metabolism in Response to Galactose Sugar
Article title: Global changes to HepG2 cell metabolism in response to galactose treatment Authors: Robert A. Skolik, Jason Solocinski, Mary E. Konkle, Nilay Chakraborty, Michael A. Menze From the authors: “Here we demonstrate that the metabolic poise in tumor-derived HepG2 cells…
Researchers Analyze Function and Mechanisms of Bifunctional Fusion Proteins Upregulated in Muscle Hypertrophy
Article title:Structural and functional characterization of engineered bifunctional fusion proteins of CD39 and CD73 ectonucleotidases Authors: Elizabeth H. Zhong, Carola Ledderose, Paola De Andrade Mello, Keiichi Enjyoji, Justin Mark Lunderberg, Wolfgang G. Junger, Simon C. Robson From the authors: “This CD39-CD73…
Study Explores Mitochondrial-directed Therapy for Carbon Monoxide Poisoning
Article title: Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide poisoned individuals Authors: Shawn Owiredu, Abhay Ranganathan, David M. Eckmann, Frances S. Shofer, Kevin Hardy, David S. Lambert, Matthew Kelly, David H. Jang…
Researchers Identify Mechanisms That Regulate Dynamics of Non-static Junctional Sarcoplasmic Reticulum in Heart Cells
Article title: Junctional sarcoplasmic reticulum motility in adult mouse ventricular myocytes Authors: Benjamin M. Drum, Can Yuan, Ana De La Mata, Nathan Grainger, L. Fernando Santana From the authors: “Our findings suggest a novel mechanism of [excitation-contraction (EC)] coupling regulation.…
Study Highlights Importance of Cellular Substrates and Physical Environment as Determinants to Cell Migration
Article title: Bioenergetics underlying single cell migration on aligned nanofiber scaffolds Authors: Abinash Padhi, Alexander H. Thomson, Justin B. Perry, Grace N. Davis, Ryan P. McMillan, Sandra Loesgen, Elizabeth N. Kaweesa, Rakesh Kapania, Amrinder S. Nain, David A. Brown From…