Neuroscientists at Macquarie University in Australia have developed a single-dose genetic medicine that has been proven to halt the progression of both ALS and frontotemporal dementia (FTD) in mice – and may even offer the potential to reverse some of the effects of the fatal diseases.
Tag: Frontotemporal Dementia
Collaboration Propels Research on Untreatable Neurodegenerative Disease
It started with a hunt for lab space and ended with a collaboration born out of what the researchers call a “cosmic coincidence.”
What is frontotemporal dementia? A neurologist explains
Less than one year after stepping away from acting due to a diagnosis of aphasia, Bruce Willis has been diagnosed with frontotemporal dementia. Here, a neurologist answers key questions about FTD.
Dementia: University of Michigan neurologists available to speak on frontotemporal dementia #FTD after Bruce Willis diagnosis
On Feb. 16, the family of Bruce Willis announced that the celebrated actor has been diagnosed with frontotemporal dementia, or FTD. It was announced in 2022 that Willis had aphasia, which can be an early sign of FTD. In wake…
New clues into a serious neurodegenerative disease
A new study sheds light on the basic biology of frontotemporal dementia caused by a particular genetic mutation
Landmark Study of Biomarker Data May Enable Better Treatment for Early Onset Dementia
In a study publishing in Nature Medicine on September 22, 2022, University of California San Francisco researchers Adam Staffaroni, PhD, and Adam Boxer, MD, PhD, combined and harmonized clinical, neuroimaging, and fluid biomarkers from nearly all familial FTD clinical research participants across North America and Europe. With that data, they developed models of clinical and biomarker dynamics to determine the temporal sequence of biomarker and clinical changes in f-FTD before disease progression begins.
Researchers link neurodegenerative disease protein to defective cholesterol metabolism
Researchers in Singapore have discovered that brain cells cannot maintain the cholesterol-rich myelin sheath that protects and insulates neurons in the absence of a protein called TDP-43. The study, which will be published August 4 in the Journal of Cell Biology (JCB), suggests that restoring cholesterol levels could be a new therapeutic approach for diseases associated with TDP-43, such as amyotrophic lateral sclerosis and frontotemporal dementia.