Tag: Sarcopenia

The silent threat of sarcopenia among elderly type 2 diabetes patients

sarah JonasResearch Results

A recent study highlights the increased risks faced by elderly patients with type 2 diabetes mellitus (T2DM) who also suffer from sarcopenia, a condition of age-related muscle loss. The findings indicate that these patients are significantly more likely to experience severe disability, rehospitalization, and even death compared to those without sarcopenia. This research underscores the importance of early detection and intervention in managing sarcopenia, aiming to improve health outcomes and quality of life for elderly diabetics. It provides crucial insights into the growing challenge of sarcopenia within this population.

Synchronisation between the central circadian clock and the circadian clocks of tissues preserves their functioning and prevents ageing

sarah JonasResearch Results

• Two complementary research articles, published simultaneously in the journals Science and Cell Stem Cell by a team of scientists from the UPF and IRB Barcelona, reveal that central and peripheral circadian clocks coordinate to regulate the daily activity of skin and muscles.
• The coordination between the two clocks (central and peripheral) guarantees 50% of the circadian functions of tissues, including vital processes such as the cell cycle, DNA repair, mitochondrial activity, and metabolism.
• Synchronisation between the central brain clock and peripheral ones prevents premature muscle ageing and improves muscle function, suggesting new strategies to tackle age-related decline through circadian rhythm modulation.

Study Explores Effects of Resistance Training in Older Adults at the Cellular Level

sarah JonasResearch Results

Aging and related diseases are associated with alterations in oxidative status and low-grade inflammation, as well as a decreased endoplasmic reticulum (ER) unfolded protein response (UPR). UPR is a functional mechanism by which cells attempt to protect themselves against ER stress. Researchers analyzed these proteins in peripheral blood mononuclear cells of elderly subjects and used computer simulation to predict the key proteins associated with these biomolecules underlying physiological adaptations to exercise. They collected blood samples about five to six days before and after the training period and analyzed various oxidative stress biomarkers in peripheral blood mononuclear cells. The study takes research one step further in helping to elucidate the benefits of exercise in this population.