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UrduA University of Michigan-led study provided evidence of the efficacy of a new drug-induced liver injury screening platform using human liver organoids, or tiny 3D models of organs developed from patients’ stem cells that grow in petri dishes.
Tag: Liver Injury
Research Unveils Paths to Stopping Cytokine Storms in COVID-19
New research from RUSH University reveals pathways to reducing organ injury caused by severe COVID-19 infection. What began as a study of how the common cold affected patients with certain types of kidney disease evolved to mitigating myocarditis, liver injury and severe kidney injury from COVID-19.
Drug-Induced Liver Injury, Translational microRNA Biomarkers, and More Featured in January 2021 Toxicological Sciences
in the January 2021 issue, Toxicological Sciences offers an engaging slate of research in toxicology, from endocrine toxicology and biomarkers to genetic and epigenetic toxicology and mixtures toxicology.
Unique Coagulation Driven by IL-6 Trans-Signaling Associated with Liver Injury in COVID-19
ALEXANDRIA, VA – Data from a new study presented this week at The Liver Meeting Digital Experience® – held by the American Association for the Study of Liver Diseases – found that COVID-19 coagulation impairment, driven in part by endothelial Factor VIII, is associated with liver injury in infected patients. The study’s findings also show that IL-6 trans-signaling, which may play a role in COVID-19 development, results in prothrombotic liver sinusoidal endothelial cells (LSECs) that may mediate the liver injury via elevated Factor VIII and activation of coagulation in the liver microvasculature.