Strawberry’s silent war: unveiling the early defense against gray mold

A pivotal study has illuminated how woodland strawberries launch rapid defense mechanisms against Botrytis cinerea, the fungus responsible for devastating gray mold. Using high-resolution RNA sequencing, researchers mapped the strawberry’s swift systemic response and the pathogen’s persistent gene activity during early infection stages. These findings are key to advancing strategies aimed at enhancing plant immunity, offering promising directions for safeguarding strawberry crops from this widespread disease.

A stealth fungus has decimated North American bats but scientists may be a step closer to treating white-nose syndrome

An invasive fungus that colonizes the skin of hibernating bats with deadly consequences is a stealthy invader that uses multiple strategies to slip into the small mammals’ skin cells and quietly manipulate them to aid its own survival. The fungus, which causes the disease white-nose syndrome, has devastated several North American species over the last 18 years.

An anti-inflammatory curbs spread of fungi causing serious blood infections

Study finds that mesalamine, a common anti-inflammatory drug, can fight the fungus Candida albicans in the gut, potentially preventing the risk of invasive candidiasis in patients with blood cancers.

Newly identified yeast could prevent fungal infections by outcompeting rivals, study suggests

Researchers at the Weizmann Institute of Science in Israel have identified a yeast that could be used to prevent invasive candidiasis, a major cause of death in hospitalized and immunocompromised patients. The study, to be published March 18 in the Journal of Experimental Medicine (JEM), shows that the novel yeast lives harmlessly in the intestines of mice and humans and can displace the yeast responsible for candidiasis, Candida albicans.

Visualizing fungal infections deep in living host tissue reveals proline metabolism facilitates virulence

An international team of scientists led by researchers from the Department of Molecular Biosciences, The Wenner-Gren Institute, SciLifeLab, Stockholm University has published in PLoS Pathogens the first successful application of 2-photon intravital microscopy (IVM) to image the dynamics of fungal infections in the kidney of a living host.

Climate change contributing to an expected rise in fungal pathogens over the next decade

Endemic mycoses, or fungal pathogens that lead to a wide range of diseases in humans, are expected to become more common in the coming decade, partly due to climate change. The increasing spread of these pathogens increases the possibility that clinicians without familiarity of the mycoses may encounter them in daily practice. This is important because endemic mycoses may be erroneously diagnosed as bacterial infections, leading to inappropriate use of antibiotics and other prescriptions that provide no relief to the patient. The commentary is published in Annals of Internal Medicine.