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UrduScientists at Sanford Burnham Prebys have developed a clearer picture of how crucial machinery in the human cell’s recycling process for obsolete and misshapen proteins—known as proteasomes—are formed.
Tag: cancer metabolism
How tumor stiffness alters immune cell behavior to escape destruction
Researchers at Sanford Burnham Prebys, with collaborators, illuminate how the fibrotic tumor microenvironment creates an inhospitable milieu for anti-tumor immunity, not just by creating a physical barrier but through metabolic changes that suppress the anti-tumor function of responding immune cells.
Cancer cells rev up synthesis, compared with neighbors
Tumors are composed of rapidly multiplying cancer cells. Understanding which biochemical processes fuel their relentless growth can provide hints at therapeutic targets. Researchers from Washington University in St. Louis have developed a technology to study tumor growth in another dimension — literally. The scientists established a new method to watch what nutrients are used at which rates spatially throughout a tissue.
Eyal Gottlieb, Ph.D., to join MD Anderson as Vice President for Research
Eyal Gottlieb, Ph.D., has been named MD Anderson’s vice president for Research. Gottlieb, an accomplished scientist and leader, will join the institution in January to uphold and expand the institution’s research excellence.
Researchers identify a mechanism that can help guide the development of new STING-activating drugs using imaging
A new study from scientists at the UCLA Jonsson Comprehensive Cancer Center found that emerging drugs that activate the protein STING, a well-established regulator of immune cell activation, substantially alter the activity of metabolic pathways responsible for generating the nucleotide building blocks for DNA.
Moffitt Receives $10.2 Million Grant to Develop New Lung Cancer Therapies
The National Cancer Institute has awarded the Lung Cancer Metabolism Working Group at Moffitt Cancer Center with a Research Program Project Grant (P01CA250984). The grant, which will provide more than $10.2 million over five years, will support team research with a focus on investigating lung cancer metabolism.
Rutgers Cancer Institute of New Jersey Awarded $1.3M for Cancer Metabolism and Growth Research Program
Rutgers Cancer Institute has received a $1.3 million, five-year grant from the National Cancer Institute to support the Cancer Metabolism and Growth and Tumor Host Interactions Training Program which will provide postdoctoral candidates the highest quality training and research experience.
Electromagnetic fields hinder spread of breast cancer, study shows
Electricity may slow – and in some cases, stop – the speed at which breast cancer cells spread through the body, a new study indicates. The research also found that electromagnetic fields might hinder the amount of breast cancer cells that spread.
Key Discoveries in Cancer Treatment to Be Presented During the Virtual 2020 AACC Annual Scientific Meeting
During the all-virtual 2020 AACC Annual Scientific Meeting & Clinical Lab Expo, leading scientific experts will dive into the groundbreaking advances that are the future of cancer care. One plenary session will focus on the cutting-edge treatment known as T cell therapy, while another will showcase recent discoveries about tumor metabolism that could lead to new, more effective cancer drugs.
New connections reveal how cancer evades the immune system
If cancer is a series of puzzles, a new study pieces together how several of those puzzles connect to form a bigger picture. A connection between three separate puzzles suggests targeting the amino acid methionine transporter in tumor cells could make immunotherapy effective against more cancers.
Study Suggests Method to Starve Pancreatic Cancer Cells
Rather than attacking cancer cells directly, new cell-model research probes weaknesses in pancreatic cancer’s interactions with other cells to obtain nutrients needed for tumor growth.
Preventing pancreatic cancer metastasis by keeping cells “sheltered in place”
Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that pancreatic cancer metastasis—when tumor cells gain the deadly ability to migrate to new parts of the body—can be suppressed by inhibiting a protein called Slug that regulates cell movement. The study, published in the Journal of Experimental Medicine, also revealed two druggable targets that interact with Slug and hold promise as treatments that may stop the spread of pancreatic cancer.