Deciphering the Functions Encoded in Phage Genomes

Bacteriophages are the most common biological entities in microbial communities, but it has been challenging to study their biology. As a result, the genomes of most phages contain many genes of unknown function. In this study, researchers developed a new CRISPR-based technology to reduce the activity of genes in phages to determine if those genes are essential.

Therapeutic Potential of Bizarre ‘Jumbo’ Viruses Tapped for $10M HHMI Emerging Pathogens Project

UC San Diego and its collaborating partners have been awarded $10 million from the Howard Hughes Medical Institute to leverage the biomedical promise of viruses known as bacteriophages as new therapeutic agents in the fight against the rising crisis of antibiotic-resistant bacterial infections.

Pitt researchers led the largest-ever series of phage therapy case studies

In a new paper published today in the journal Clinical Infectious Diseases, a team led by researchers from the University of Pittsburgh and the University of California San Diego report 20 new case studies on the use of the experimental treatment, showing the therapy’s success in more than half of the patients.