High Levels of a Specific Antibody May Contribute to Acute Coronary Syndrome

How a person’s immune system responds to a protein called LL-37 may increase risk for developing acute coronary syndrome, but the response may also serve as a potential target for future treatments.

Study identifies new pathway to suppressing autoimmunity

Researchers at Stanford University School of Medicine, Yale University School of Medicine, and the Hospital for Special Surgery Research Institute have uncovered new details about how the immune system prevents the production of antibodies that can recognize and damage the body’s own, healthy tissues. The study, to be published September 29 in the Journal of Experimental Medicine (JEM), also reveals how this process is impaired in autoimmune disorders such as systemic sclerosis and systemic lupus erythematosus and suggests potential new strategies to treat these diseases.

Holding Mycophenolate Mofetil for 10 Days or More May Improve COVID-19 Vaccine Response

New research presented this week at ACR Convergence 2022, the American College of Rheumatology’s annual meeting, demonstrated that withholding mycophenolate mofetil for 10 days significantly increased antibody response after 2 doses of COVID-19 vaccine, without a significant increase in flares.