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Tag: Oncogenes
PRMT5-mediated arginine methylation of FXR1 is essential for RNA binding in cancer cells
Background: Our findings explain one of the molecular mechanisms of FXR1’s reported tumorigenic role in HNSCC and lay the groundwork for future research into how targeting the interface between FXR1 and PRMT5 can affect gene expression and aid in the development…
St. Jude tool targets cancer-causing fusions’ weak spot
Scientists at St. Jude Children’s Research Hospital comprehensively characterized oncogenic fusions in pediatric cancer, providing proof-of-principle for genetic engineering-based therapies.