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UrduGenetic researchers at the UNC School of Medicine have identified a key focal point in the biological processes that control cell identity and can lead to disease when mutated.
Tag: Methylation
Missing a Rare Cause of Hereditary Cancer
New research from Cedars-Sinai Cancer investigators could warrant reconsideration of current screening guidelines to include a poorly recognized cause of Lynch syndrome, the most common cause of hereditary colorectal and endometrial cancers.
Methylated cyclodextrin effectively prevents the crystallization of supersaturated drugs
In the medicine market, most newly introduced drugs and drug candidates show poor water solubility, which prevents their absorption in the body. This, in turn, limits their therapeutic efficiency.
Found! Lost Puzzle Piece Involved in Gene Regulation Revealed in Search That Began in Water-Loving, One-Celled Organism
After an intrepid, decade-long search, Johns Hopkins Medicine scientists say they have found a new role for a pair of enzymes that regulate genome function and, when missing or mutated, are linked to diseases such as brain tumors, blood cancers and Kleefstra syndrome — a rare genetic, neurocognitive disorder.
Algorithm Created By “Deep Learning” Identifies Potential Therapeutic Targets Throughout Genome
A team of researchers have developed an algorithm through machine learning that helps predict sites of DNA methylation – a process that can change the activity of DNA without changing its overall structure – and could identify disease-causing mechanisms that would otherwise be missed by conventional screening methods.
How Old Is Your Dog in Human Years? Scientists Develop Better Method than ‘Multiply by 7’
By mapping molecular changes in the genome over time, UC San Diego researchers developed a formula to more accurately compare dog age to human age — a tool that could also help them evaluate how well anti-aging products work.
Surprise discovery shakes up our understanding of gene expression
A group of University of Chicago scientists has uncovered a previously unknown way that our genes are made into reality. Rather than directions going one-way from DNA to RNA to proteins, the latest study shows that RNA itself modulates how DNA is transcribed—using a chemical process that is increasingly apparent to be vital to biology. The discovery has significant implications for our understanding of human disease and drug design.