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UrduTwo new discoveries led by Cedars-Sinai Cancer investigators help improve the understanding of what drives the development of ovarian cancer and why some women’s tumors do not respond to therapy.
Tag: Chemotherapy resistance
Computer Simulations of Proteins Help Unravel Why Chemotherapy Resistance Occurs
Understanding why and how chemotherapy resistance occurs is a major step toward optimizing treatments for cancer. A team of scientists including Markus Seeliger, PhD, of the Renaissance School of Medicine at Stony Brook University, believe they have found a new process through which drug resistance happens.
Therapeutic resistance linked to softer tissue environment in breast cancer
Researchers at the University of California, San Francisco, have discovered that aggressive, triple-negative breast cancers (TNBCs) can evade treatment by reorganizing and softening the collagen matrix that surrounds the cancer cells. The study, which will be published April 2 in the Journal of Experimental Medicine (JEM), shows that the softer matrix activates a signaling pathway that promotes the cancer cells’ survival, and suggests that targeting this pathway could enhance the effectiveness of chemo- and radiotherapy in TNBC patients.