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UrduScientists know that TDP-43, which helps regulate processing of RNA, may be responsible for the death of nerve cells in ALS and frontotemporal dementia. And a study suggests that a common modification to RNA, a methylation event known as m6A, plays a pivotal role in TDP-43-related neurodegeneration in ALS. Through sequencing analysis, investigators showed that methylation strongly influences the binding of TDP-43 to its RNA targets. They also observed highly abundant RNA methylation in the end-stage tissues of patients with ALS.
Tag: Lou Gehrig disease
Mount Sinai Researchers Learn That ALS May Be Linked to Both the Immune and Central Nervous Systems
New York, NY (June 22, 2022) – The immune system may play a fundamental role along with the central nervous system in amyotrophic lateral sclerosis (ALS), also known as “Lou Gehrig’s disease,” Mount Sinai researchers report. Their study, published…
ALS Research Partnership Showing Promising Results
Research on a potential therapy for amyotrophic lateral sclerosis (ALS) that’s taking place in a University at Albany chemistry lab is showing promising results.
Protein Linked to ALS/Ataxia Could Play Key Role in Other Neurodegenerative Disorders
A new study suggests that some neurological disorders share a common underlying thread. Staufen1, a protein that accumulates in the brains of patients with certain neurological conditions, is linked to amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, along with other neurological disorders, including Alzheimer’s, Parkinson’s, and Huntington’s disease, according to University of Utah Health scientists.