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UrduIn APL Bioengineering, researchers employed analysis tools and machine learning algorithms to identify two genes linked to rheumatoid arthritis and osteoporosis that could serve as diagnostic tools and potential targets for treatments. Drawing from a large database of genetic information, they gathered dozens of sequenced genomes from people with rheumatoid arthritis and osteoporosis to look for any similarities, using recently developed computational methods to narrow down their search. They identified genes ATXN2L and MMP14 as significantly associated with the progression of both rheumatoid arthritis and osteoporosis.
Tag: Apoptosis
Pretreatment can alleviate programmed cell death in mesenchymal stem cells
In this editorial, we delved into the article titled “Cellular preconditioning and mesenchymal stem cell ferroptosis.” This groundbreaking study underscores a pivotal discovery: Ferroptosis, a type of programmed cell death, drastically
Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells
BACKGROUNDEmbryonic stem cells (ESCs) serve as a crucial ex vivo model, representing epiblast cells derived from the inner cell mass of blastocyst-stage embryos. ESCs exhibit a unique combination of self-renewal potency, unlimited prolifera
Effects of high glucose and severe hypoxia on the biological behavior of mesenchymal stem cells at various passages
BACKGROUNDMesenchymal stem cells (MSCs) have been extensively studied for therapeutic potential, due to their regenerative and immunomodulatory properties. Serial passage and stress factors may affect the biological characteristics of MSCs,
Sandalwood Oil By-product Prevents Prostate Cancer Development in Mice
Sandalwood oil has been used worldwide for centuries. Now, a study is the first to demonstrate in vivo the chemo-preventive properties of a by-product of the oil in a mouse model. Results show administering alpha-santalol reduced visible prostate tumors, protected the normal tissue, and delayed progression from a precancerous condition to a high-grade form of cancer. These findings are significant because mortality in prostate cancer patients is mainly attributable to advanced stages of the disease.
NUS study: Black cardamom effective against lung cancer cells
In Indian Ayurvedic medicine, black cardamom has been used in formulations to treat cancer and lung conditions. A team of NUS researchers studied the scientific basis behind this traditional medicinal practice and provided evidence of the cytotoxic effect of black cardamom on lung cancer cells. The findings could potentially lead to the discovery of safe and effective new bioactives which can prevent or cure cancer formation.
Defining Plasma Dose for Potential Future Cancer Treatments
Chinese researchers may have found a new approach to treat cancer by using a plasma treatment to induce apoptosis, without any obvious side effect to normal cells. A plasma-activated medium (PAM) can be treated as a drug, with a dose-effect relationship. In Physics of Plasmas, the scientists’ definition of a plasma dose, the equivalent total oxidation potential (ETOP), can be used for PAM to reveal the plasma dose-response relationship for different cell types.
‘Fortunate Accident’ May Yield Immunity Weapon Against Antibiotic-Resistant Bacteria
In what turned out to be one of the most important accidents of all time, Scottish bacteriologist Alexander Fleming returned to his laboratory after a vacation in 1928 to find a clear zone surrounding a piece of mold that had infiltrated a petri dish full of Staphylococcus aureus (S. aureus), a common skin bacterium he was growing.