Targeting the uncommon: advances in detecting and treating rare genetic variants of colorectal cancer

Recent research highlights the importance of targeted therapies for treating advanced colorectal cancer (CRC) with rare genetic variants. These mutations, often linked to poor prognosis and limited response to conventional treatments, are being addressed through advanced sequencing technologies and new targeted drugs. This study explores the clinical diagnosis and treatment strategies tailored to these unique genetic profiles.

Dynamic, personalized treatment approach may improve outcomes in gastroesophageal cancers

A phase 2 clinical trial providing personalized treatments based on the genetic profile of metastatic tumors in gastroesophageal cancers has found that using customized treatment approaches, and adapting them over time as tumors become resistant, led to higher rates of survival compared to historical controls.