Tag: KRAS mutation

Lung Cancer Cells Have Differential Signaling Responses to KRAS Inhibitor Treatment with Important Implications for Emerging Clinical Trials

sarah JonasResearch Results

In a new article published in Clinical Cancer Research, Moffitt Cancer Center researchers show that various subtypes of lung cancer cells activate different signaling pathways in response to KRASG12C inhibitor treatment. These results may help identify potential combination therapy approaches and guide treatment decisions for lung cancer patients in the future.

MD Anderson and Mirati Therapeutics announce KRAS strategic research and development collaboration in solid tumors

sarah JonasAnnouncement

The University of Texas MD Anderson Cancer Center and Mirati Therapeutics, Inc. today announced a strategic research and development collaboration to expand the evaluation of Mirati’s two investigational small molecule, potent and selective KRAS inhibitors – adagrasib (MRTX849), a G12C inhibitor in clinical development, and MRTX1133, a G12D inhibitor in preclinical development, as monotherapy and in combination with other agents – which target two of the most frequent KRAS mutations in cancer.

Targeted inhibitor of mutated KRAS gene shows promise in early trial for lung, bowel, and other solid tumors

sarah JonasResearch Results

A novel agent that targets a mutated form of the KRAS gene – the most commonly altered oncogene in human cancers and one long considered “undruggable” – shrank tumors in most patients in a clinical trial with manageable side effects, researchers reported today at the 32nd EORTC-NCI-AACR Symposium on Molecular Targets and Therapeutic, which is taking place online.