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UrduChunyu Wang, M.D., Ph.D., professor of biological sciences and chemistry and chemical biology at Rensselaer Polytechnic Institute, has been awarded a five-year grant of more than $3.7 million by the National Institutes of Health’s National Institute on Aging to study Apolipoprotein E (ApoE) isoform interactions with heparan sulfate (HS) in Alzheimer’s disease (AD).
Tag: Isoforms
Identifying cancer genes’ multiple personalities
Mutations in our genes can lead to severe problems, like colon or liver cancer. But cancer is very complex. Mutations in the same genes can lead to different subtypes of tumors in different people. Currently, scientists don’t have a good way to produce such tumor subtypes for study in the lab.
Gene Messengers, Rather Than Genes, May Provide Best Disease Clues
Genes can be expressed in different ways depending on how cells process their messengers, aka splicing isoforms. Genetic mutations can damage some splicing isoforms but not others. UC San Diego School of Medicine researchers found that splicing isoforms hit by…