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UrduA RIPE team used CRISPR/Cas9 to increase gene expression in rice by changing its upstream regulatory DNA. Their work is the first unbiased gene-editing approach to increase gene expression and downstream photosynthetic activity and was recently published in Science Advances.
Tag: crispr cas9
Using Advanced Genetic Techniques, Scientists Create Mice With Traits of Tourette Disorder
In research that may be a step forward toward finding personalized treatments for Tourette disorder, scientists at Rutgers University–New Brunswick have bred mice that exhibit some of the same behaviors and brain abnormalities seen in humans with the disorder. As reported in the Proceedings of the National Academy of Sciences, the researchers, using a technique known as CRISPR/Cas9 DNA editing, inserted the same genetic mutations found in humans with Tourette disorder into the corresponding genes in mouse embryos.
Technology Developed at Rutgers Sublicensed to Global Biopharmaceutical Company
Base editing technology invented at Rutgers, The State University of New Jersey, and exclusively licensed to Revvity, Inc. subsidiary Horizon Discovery, has been sub-licensed to biopharmaceutical company AstraZeneca to support its creation of cell therapies for the treatment of cancer and immune-mediated diseases.
Eliminating RNA-binding protein improves survival in aggressive leukemia
Removing a protein that is often overexpressed in a rare and aggressive subtype of leukemia can help to slow the cancer’s development and significantly increase the likelihood of survival, according to a study in mice led by scientists at the UCLA Jonsson Comprehensive Cancer Center.