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UrduWorking with human breast and lung cells, Johns Hopkins Medicine scientists say they have charted a molecular pathway that can lure cells down a hazardous path of duplicating their genome too many times, a hallmark of cancer cells.
Tag: Cell Cycle
Breast cancer by age: Study reveals early mutations that predict patient outcomes
A study led by researchers at Sanford Burnham Prebys has found that in young women, certain genetic mutations are associated with treatment-resistant breast cancer.
MD Anderson Research Highlights for February 1, 2023
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Beyond the average cell
Models based on an average cell are useful, but they may not accurately describe how individual cells really work. New possibilities opened up with the advent of single-cell live imaging technologies. Now it is possible to peer into the lives of individual cells. In a new paper in PLOS Genetics, a team of biologists and physicists from Washington University in St. Louis and Purdue University used actual single-cell data to create an updated framework for understanding the relationship between cell growth, DNA replication and division in a bacterial system.
A direct protein-to-protein binding couples cell survival to cell proliferation
The regulators of apoptosis watch over cell replication and the decision to enter the cell cycle. Researchers now show a direct link between the protein MCL1 — a member of the BCL2 protein family known as the gatekeepers of apoptosis — and the cell-cycle checkpoint protein P18.
To divide or not to divide? The mother cell may decide
Researchers at CU Boulder have found that it’s the mother cell that determines if its daughter cells will divide. The finding, explained in a new study out today in Science, sheds new light on the cell cycle using modern imaging technologies, and could have implications for cancer drug therapy treatments.
Colorado study overturns ‘snapshot’ model of cell cycle in use since 1974
Live, single-cell imaging shows that cells continuously integrate the influence of growth factors, not just during G1 phase of cell cycle, as previously thought.