Adolescent Alcohol Exposure Impairs Behavioral Flexibility and Learning in Adult Rats, Pointing to Persistent Effects on Brain Chemistry

Rats with alcohol exposure in adolescence are less able as adults to adapt their behavior in changing circumstances, according to a study that highlights the possible brain mechanisms involved. The findings may help us better understand ways that alcohol use during the teen years can lead to long-lasting cognitive and behavioral impairments.

A genetic predisposition to alcohol use is not the same as a genetic destiny for alcohol misuse

There is a clear relationship between alcohol and neurodegeneration; for example, an alcohol use disorder correlates with a higher risk of Alzheimer’s disease. It is unclear, however, whether individual differences in brain structure and connectivity are risk factors for, or consequences of, alcohol use. New research exploring this relationship will be shared on Wednesday, 26 June 2024 at the 47th annual scientific meeting of the Research Society on Alcohol (RSA) in Minneapolis, Minnesota.