Study Reveals Mechanisms that May Drive Sex Differences in Diuretic Response

Article title: Distal convoluted tubule sexual dimorphism revealed by advanced 3D imaging

Authors: Ebrahim Tahaei, Richard Coleman, Turgay Saritas, David H. Ellison, Paul A. Welling

From the authors: “Female mice expressed a greater density of [sodium cotransporters] in a shorter structure to protect [sodium] balance in the face of greater basal distal [sodium] delivery yet have a larger reserve and structural remodeling capacity to adapt to unique physiological stresses.”

This study is highlighted as one of November’s “best of the best” as part of the American Physiological Society’s APSselect program.