Researchers Explore Sex Differences in Cardiovascular and Congenital Heart Diseases in People with Down Syndrome

Article title: Sex differences in cardiovascular disease and dysregulation in Down syndrome

Authors: Melissa L. Bates, Anastasiia Vasileva, Laura D.M. Flores, Yana Pryakhina, Michelle Buckman, Michael H. Tomasson, Lara R. DeRuisseau

From the authors: “Based on the results of our scoping review, we conclude female individuals with [Down syndrome] are at higher risk of cardiotoxicity from chemotherapy, coronary disease and Moyamoya syndrome, relative to the general population. The scoping review was mixed for increased female risk for [congenital heart disease], whereas the retrospective medical record review detected a higher risk for males with [Down syndrome] across the ages we studied.”

This study is highlighted as one of April’s “best of the best” as part of the American Physiological Society’s APSselect program.