The burden of disease is substantial and affects development and quality of life. Children with myelomeningocele require surgical intervention at birth to close the spinal defect. Most infants with myelomeningocele have hydrocephalus and require surgical treatment. There is currently little agreement among leading practitioners about the optimal timing of closure of the myelomeningocele defect of the spine. There are differences in practice with regards to team approach to closure, type of closure techniques, administration of antibiotics, and benefits of amputation or preservation of the neural placode. Additionally, as technology advances, in utero (or fetal) closure of the myelomeningocele defect has been advocated by many experts, but the long-term positive and negative effects of in utero closure have not been well studied. While in utero closure of myelomeningocele is an option for some pregnant women whose infants met criteria for diagnosis of Spina Bifida as fetuses, globally, this option is not readily available.
This systematic review was conducted to evaluate all available evidence to aid clinicians and guide clinical practice by determining the best options for management of pediatric myelomeningocele. Guidelines authors aimed to systematically review the literature and make evidence based recommendations about the timing of closure after birth, and to investigate the evidence concerning persistent ventriculomegaly and cognitive impairment. The goals of this effort were to discern the most effective strategies for a variety of myelomeningocele-related problems, including the timing and type of closure for myelomeningocele. The authors also considered the use of technical advances such as in utero or fetal closure, closure techniques, endoscopic treatment of hydrocephalus/ventriculomegaly, and other factors affecting infants and children with myelomeningocele. According to Dr. David Bauer, “it is the Guideline Task Force’s aim that these systematic reviews and subsequent evidence based recommendations will lead to improvement in the quality of life for infants and children with myelomeningocele.”
These clinical practice guidelines include five clinical questions pertaining to patients with myelomeningocele and provide seven recommendations.
This evidence based guideline and systematic review of the literature relevant to infants and children with myelomeningocele were accomplished in order to hopefully improve the quality of life for patients with myelomeningocele globally. Dr. Catherine Mazzola (Task Force Chair) states, “The life-long effects of myelomeningocele are profound and complex, and for children living in third world nations, may prove fatal, in many cases. It is through continued critical research efforts as specialists who treat these children that possibly one day researchers may find better treatment and eventually, a cure for myelomeningocele.”
These guidelines were developed by the CNS and endorsed by the CNS, the American Association of Neurological Surgeons and the Spina Bifida Association.
About the Congress of Neurological Surgeons
The Congress of Neurological Surgeons (CNS) is the global leader in neurosurgical education, serving to promote health by advancing neurosurgery through innovation and excellence in education. The CNS provides leadership in neurosurgery by inspiring and facilitating scientific discovery and its translation into clinical practice. The CNS maintains the vitality of the profession through volunteer efforts of its members and the development of leadership in service to the public, to colleagues in other disciplines, and to neurosurgeons throughout the world in all stages of their professional lives. For more information, visit cns.org
scraped from https://www.newswise.com/articles/cns-publishes-guidelines-for-pediatric-myelomeningocele