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Critical care specialists debate best management strategy for sepsis and septic shock

February 13, 2023 sarah JonasResearch Results

In a new Annals ‘Beyond the Guideline’s feature, two critical care specialists discuss and debate conditional guideline recommendations on using lactate to guide resuscitation, the use of balanced crystalloids versus normal saline, and the use of corticosteroids for management of sepsis and septic shock. All ‘Beyond the Guidelines’ features are based on the Department of Medicine Grand Rounds at Beth Israel Deaconess Medical Center (BIDMC) in Boston and include print, video, and educational components published in Annals of Internal Medicine.

What Makes Blood Vessels Leaky: New Insights for Sepsis Therapeutics

August 31, 2021 sarah JonasResearch Results

Lab studies reveal protein HSP27’s role in blood vessel leakage, opening the possibility that therapeutically dialing its activity up or down might stabilize patients with sepsis.

Early Steroids Improve Outcomes in Patients with Septic Shock

September 14, 2020 sarah JonasResearch Results

Some critically ill patients with septic shock need medications called vasopressors to correct dangerously low blood pressure. When high doses of vasopressors are needed or blood pressure isn’t responding well, the steroid hydrocortisone is often used. In this situation, earlier treatment with hydrocortisone reduces the risk of death and other adverse outcomes, reports a study in SHOCK®: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches, Official Journal of the Shock Society. The journal is published in the Lippincott portfolio by Wolters Kluwer.

Sepsis: Using Big Data to Cut a Killer Down to Size

February 19, 2020 sarah JonasFeature Expert

Sepsis causes nearly 270,000 deaths in the United States each year. Find out how big data approaches are helping clinicians catch it sooner, treat it better, and help survivors cope with long-term effects.