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UrduThe relentless neurological disease amyotrophic lateral sclerosis (ALS) eventually shuts down the entire body, but the devastation starts at a molecular level. The possibility of stopping the disease by repairing and preserving proteins in the brain has inspired experiments in the lab of Meredith Jackrel, an assistant professor of chemistry in Arts & Sciences at Washington University in St. Louis.
Tag: Misfolded Protein
Protein Shapes Matter in Alzheimer’s Research
Even small changes may have big, long-term consequences. For amyloid beta peptides, a major hallmark of Alzheimer’s disease, a common chemical modification at a particular location on the molecule has a butterfly effect that leads to protein misfolding, aggregation and cellular toxicity.