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UrduThe development of versatile and efficient biocatalysts for the synthesis of α-hydroxyketones and Ephedra-type alkaloids represents a significant advancement in synthetic biology and medicinal chemistry. In this study, researchers explore the potential of acetolactate synthase (AlsS) from Bacillus subtilis (BsAlsS) for the production of phenylacetylcarbinol (PAC) and its derivatives. Additionally, the study investigates the use of intermediate reductive amination enzymes (introduction of amine group using enzymes) for functionalizing α-hydroxyketones to generate synthetic Ephedra-type alkaloids.
Tag: enzyme engineering
Structure of ‘Oil-Eating’ Enzyme Opens Door to Bioengineered Catalysts
Scientists at Brookhaven National Laboratory have produced the first atomic-level structure of an enzyme that selectively cuts carbon-hydrogen bonds—the first and most challenging step in turning simple hydrocarbons into more useful chemicals. The detailed atomic level “blueprint” suggests ways to engineer the enzyme to produce desired products.
Evolutionary ‘time travel’ reveals enzyme’s origins, possible future designs
“The distinction between the past, present and future is only a stubbornly persistent illusion,” Albert Einstein wrote. Now, researchers have used evolutionary “time travel” to study how an enzyme has evolved, with implications for future design. They will present their results at ACS Fall 2021.