Myocardial infarction, or heart attacks, play a large part in heart diseases and the necrosis of cardiac tissue. In APL Bioengineering, researchers take stock of stem cell-laden 3D-bioprinted cardiac patch technologies and their efficacy as a therapeutic and regenerative approach for ischemic cardiomyopathy in reversing scar formation and promoting myocardial regeneration. They explore types of candidate stem cells that possess cardiac regenerative potential and share updates on the challenging implementation of the state-of-the-art 3D-bioprinting approach.