Tag: DNA nanotechnology

NUS researchers develop revolutionary technology to unravel complex protein interactions that could transform cancer diagnostics

sarah JonasResearch Results

A team of researchers from NUS Institute for Health Innovation & Technology (iHealthtech), led by Associate Professor Shao Huilin and Associate Professor Brian Lim, has developed a first-of-its-kind technology to map out diverse protein interactions in cells using DNA barcodes.

The technology, dubbed TETRIS, can explicitly identify and quantify multiple interacting partners in large protein assemblies. By capturing the complex hierarchy of protein interactions within tumour cells, the technology uncovers detailed molecular mechanisms driving disease progression. This enables more precise diagnostics, allowing for the accurate sub-typing of cancers and the identification of aggressive forms of the disease in just a few hours, which was not possible previously.

Building Tough 3D Nanomaterials with DNA

sarah JonasResearch Results

Columbia Engineering researchers, working with Brookhaven National Laboratory, report today that they have built designed nanoparticle-based 3D materials that can withstand a vacuum, high temperatures, high pressure, and high radiation. This new fabrication process results in robust and fully engineered nanoscale frameworks that not only can accommodate a variety of functional nanoparticle types but also can be quickly processed with conventional nanofabrication methods.