Macrophages Play Important Role in Pediatric Obesity-associated Kidney Disease

Article title: Depletion of macrophages slows the early progression of renal injury in obese Dahl salt-sensitive leptin receptor mutant rats

Authors: Bibek Poudel, Corbin A. Shields, Andrea K. Brown, Ubong Ekperikpe, Tyler Johnson, Denise C. Cornelius, Jan M. Williams

From the authors: “[M]acrophages play an important role in the early development and progression of renal disease associated with obesity before puberty, but further studies are needed to determine the potential mechanisms involved in renal injury secondary to macrophage activation.” 

This study is highlighted as one of July’s “best of the best” as part of the American Physiological Society’s APSselect program.

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