Estrogen’s Regulation of ACE2 Expression in Lungs Could Explain COVID-19 Sex Differences

Article title: Estrogen regulates the expression of SARS-CoV-2 receptor ACE2 in differentiated airway epithelial cells

Authors: Kimberly E. Stelzig, Fabrizio Canepa-Escaro, Marta Schiliro, Sergejs Berdnikovs, Y. S. Prakash, Sergio E. Chiarella

From the authors: “Given the striking sexual dimorphism in the COVID-19 pandemic, it is important to further elucidate the mechanisms by which sex hormones regulate the cellular components required for SARS-CoV-2 infectivity and ability to cause life-threatening disease.” 

This study is highlighted as one of July’s “best of the best” as part of the American Physiological Society’s APSselect program.

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