UC Irvine-led study links long-term air pollution exposure to postpartum depression in SoCal

Irvine, Calif., Oct. 31, 2023 — Long-term maternal exposure to common air pollutants, both before and after childbirth, has been linked to increased risk of postpartum depression for mothers – with symptoms ranging from anxiety and irritability to suicide – and may lead to cognitive, emotional, psychological and behavioral impairments in their infants, according to research led by the University of California, Irvine.

The study, recently published online in JAMA Network Open, is one of the first to examine the association between environmental factors and this clinical disorder that affects approximately 10 to 20 percent of women after childbirth worldwide.

“Postpartum depression is a major public health problem,” said corresponding author Jun Wu, Ph.D., UCI professor of environmental and occupational health. “Due to increased susceptibility of mothers during the antepartum and postpartum periods, identifying modifiable environmental risk factors is important, as it can support future intervention studies on reducing the rate of PPD.”

The team conducted a retrospective cohort study of 340,679 women included in the Kaiser Permanente Southern California electronic health records who had live singleton births at KPSC facilities between Jan. 1, 2008, and Dec. 31, 2016, with a mean age of 30 years. Ambient air exposures were assessed based on maternal residential addresses using monthly averages of ozone; nitrogen oxides; particulate matter less than or equal to 10 micrometers, such as dust; and fine particulate matter less than or equal to 2.5 micrometers, which contains a mixture of chemicals such as sulfate, nitrate and black carbon.

Overall, a higher risk of PPD was associated with exposure to ozone during the entire pregnancy and postpartum period and with exposure to constituents of fine particulate matter – including organic matter and black carbon – during late pregnancy and postpartum. Findings also showed that specific demographics were most vulnerable to ante- and postpartum exposures to these common pollutants, including mothers aged 25 to 34, African American or Hispanic women, those with higher education and those who were underweight.

“We want to raise awareness of the significant impact that [air pollution] has on pregnant women, new moms and their families, and we’ll conduct further research to explore the joint effects of multiple stressors, including social factors such as race and socioeconomic status and environmental factors such as air pollution, noise and lack of green space,” said first author Yi Sun, Ph.D., previously a UCI postdoctoral researcher and currently a researcher at the Chinese Academy of Medical Sciences’ Institute of Medical Information. “With more evidence from future studies, we hope to identify modifiable environmental risk factors to support interventions, such as the use of air filters or masks for the most vulnerable groups of pregnant and postpartum women.”

The international research team also comprised faculty, scientists, graduate students and healthcare professionals from UCI, KPSC, USC, Oregon State University and Scripps Institution of Oceanography. A complete listing can be found here.

This work was supported by a grant from the National Institute of Environmental Health Sciences under award number R01ES030353.

About the University of California, Irvine: Founded in 1965, UCI is a member of the prestigious Association of American Universities and is ranked among the nation’s top 10 public universities by U.S. News & World Report. The campus has produced five Nobel laureates and is known for its academic achievement, premier research, innovation and anteater mascot. Led by Chancellor Howard Gillman, UCI has more than 36,000 students and offers 224 degree programs. It’s located in one of the world’s safest and most economically vibrant communities and is Orange County’s second-largest employer, contributing $7 billion annually to the local economy and $8 billion statewide. For more on UCI, visit www.uci.edu.

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