Intense Training Disturbs Tendon Homeostasis, Leads to Injury

Michael Kjaer, MD, PhD, of Copenhagen University and Bispebjerg Hospital in Denmark, will discuss the effects of exercise and sedentary behavior on tendon loading and collagen turnover. “The collagen turnover in tendon can be up- and down-regulated with exercise or inactivity, respectively, and specific parts of the tendon are responsible for this loading-induced collagen dynamics. Long-term overuse of tendon (e.g., intense training) results in disturbed homeostasis and swelling of the tendon, excess angiogenesis and upregulated formation of collagen,” Kjaer wrote.

Circadian Clock Regulates Body’s Collagen Production

Researchers featured in the “Homeostasis and adaptation of tendons to exercise” symposium—presented this week virtually at the American Physiological Society (APS) Integrative Physiology of Exercise conference—will discuss how exercise, inactivity and the body’s internal clock drive structural changes to tendons and their supportive tissues.