Intense Training Disturbs Tendon Homeostasis, Leads to Injury

Michael Kjaer, MD, PhD, of Copenhagen University and Bispebjerg Hospital in Denmark, will discuss the effects of exercise and sedentary behavior on tendon loading and collagen turnover. “The collagen turnover in tendon can be up- and down-regulated with exercise or inactivity, respectively, and specific parts of the tendon are responsible for this loading-induced collagen dynamics. Long-term overuse of tendon (e.g., intense training) results in disturbed homeostasis and swelling of the tendon, excess angiogenesis and upregulated formation of collagen,” Kjaer wrote.

The research will be presented virtually at the American Physiological Society (APS) Integrative Physiology of Exercise (IPE) conference. Request the Abstract: “Cellular and molecular responses to exercise and inactivity in human tendon loading”