Disadvantaged neighbourhoods and depression symptoms associated with premature aging

This study used two DNA methylation-based estimators, known as epigenetic clocks, to examine aging at the cellular level and estimate the difference between chronological age and biological age. Findings showed that neighbourhood deprivation and depressive symptoms were positively associated with acceleration of the epigenetic age estimated using the DNAm GrimAge clock.

Is weakness the new smoking? Muscle strength tied to biological age, study shows

Muscle weakness marked by grip strength is associated with accelerated biological age, a new study suggests. Results were found using “age acceleration clocks” based on DNA methylation, a process that provides a molecular biomarker and estimator of the pace of aging. Researchers say this suggests potential to adopt use of grip strength as a way to screen individuals for future risk of functional decline, chronic disease and early mortality.