Protein Mutations Alter Heart Function, Signaling Pathways in Dilated Cardiomyopathy

Article title: Dilated cardiomyopathy mutations in thin-filament regulatory proteins reduce contractility, suppress systolic Ca2+, and activate NFAT and Akt signaling

Authors: Paul Robinson, Alexander J. Sparrow, Suketu Patel, Marta Malinowska, Svetlana N. Reilly, Yin-Hua Zhang, Barbara Casadei, Hugh Watkins, Charles Redwood

From the authors: “We have found that [dilated cardiomyopathy] mutations in proteins that regulate the contractile machinery cause alterations to contraction, calcium-handling and some new signaling pathways that provide stimuli for disease development.” 

This study is highlighted as one of September’s “best of the best” as part of the American Physiological Society’s APSselect program.