IL-28 Cytokine’s Epithelial Barrier Regulation May Lead to Targeted Treatment for Crohn’s Disease

Article title: Interleukin-28A induces epithelial barrier dysfunction in [Crohn’s disease] patient-derived intestinal organoids

Authors: Pan Xu, Heike Becker, Montserrat Elizalde, Marieke Pierik, Ad A.M. Masclee, Daisy M.A.E. Jonkers

From the authors: “These results identified IL-28A as a novel regulator of epithelial barrier function and could be a putative target for [Crohn’s disease] treatment. We provide novel basic evidence that restoring intestinal barrier is a potential mechanism that contributes to the clinical benefits of JAK1 inhibitor in [Crohn’s disease] patients.” 

This study is highlighted as one of April’s “best of the best” as part of the American Physiological Society’s APSselect program.