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UrduThe Harrington Discovery Institute — part of The Harrington Project for Discovery & Development — was established in 2012 to accelerate promising discoveries into new medicines to address unmet patient needs. Approximately 350 million people worldwide are living with a rare disease, and half of them are children. With more than 7,000 known rare diseases, and only five percent of those having an approved treatment, rare diseases represent one of the greatest unmet needs in healthcare today.
Through its UK charity, Fund for Cures UK, Harrington Discovery Institute issued a national call for proposals in January 2020 for cutting-edge research related to rare diseases, ultra-rare diseases, and rare variants of more common diseases. In addition to grant funding, the award provides dedicated drug discovery and development support from Harrington Discovery Institute’s Therapeutics Development team (experienced pharma and business development professionals with a track record of bringing new drugs to market), while taking no rights to intellectual property, which is retained by the award recipient (‘Harrington Scholar’) and their institution.
Nearly 50 applications from scientists and physicians in 17 institutions across England, Scotland and Wales were received in response to the call. The applications progressed through multiple rounds of confidential review from both academic and industry science reviewers who evaluated the projects on the likelihood to improve standard of care, be transformative, and/or result in a licensable package, among other criteria.
“In eight years we have built a strong portfolio of breakthrough science throughout the US and Canada, and we are excited to extend our reach to the United Kingdom. Together with our Scholars and their institutions, we are pleased to move one step closer to changing the rare disease landscape in a meaningful way,” said Jonathan S. Stamler, MD, President, Harrington Discovery Institute, Robert S. and Sylvia K. Reitman Family Foundation Distinguished Professor of Cardiovascular Innovation and Professor of Medicine at University Hospitals and Case Western Reserve University.
The national grant award program is part of a broader commitment to advance rare disease treatments by working collaboratively with UK institutions. In 2019, Harrington Discovery Institute and the University of Oxford announced their transatlantic partnership to establish the Oxford-Harrington Rare Disease Centre (OHC). The OHC is focused primarily on rare diseases that have a clear genetic basis, present early in life, and fit one of three research themes: neurological disorders, developmental disorders, and cancer. Harrington UK Rare Disease Scholars may have opportunity to utilize Oxford’s core labs as well as the OHC Therapeutic Accelerator (planned opening in 2021) for their projects.
“The Harrington model is a bold approach that de-risks clinical drug candidates and validates their commercial potential, making them attractive to for-profit funders who are able to bring them to market. This program is an extraordinary opportunity for UK researchers to help them translate scientific discoveries into medicines that improve the lives and health outcomes of those living with a rare disease,” said Peter Worrall, former Chief Financial Officer at Rex Bionics plc, and member, Board of Trustees, Fund for Cures UK.
Harrington Discovery Institute will raise capital to support the growth of the UK rare disease initiative through Morgan Stanley GIFT Cures, its philanthropic partnership with global financial services firm Morgan Stanley.
The 2021 Harrington UK Rare Disease Scholar Award recipients, their organizations and fields of research are:
Pietro Fratta, MD, PhD – University College London
Gene Therapy for Kennedy’s Disease, a rare neuromuscular disease
Angela Russell, DPhil – University of Oxford
New Drugs for the Treatment of Duchenne Muscular Dystrophy
Helen Waller-Evans, DPhil – Cardiff University
Novel Inhibitors to Treat Multiple Lysomal Storage Disorders, causes of widespread organ damage
Wyatt Yue, PhD – University of Oxford
Inhibitors of Primary Hyperoxaluria, a cause of kidney failure
Haiyan Zhou, MD, PhD – University College London
Novel Therapy for SPTLC1-Related Hereditary Sensory Neuropathy, a cause of shooting pain
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About Harrington Discovery Institute
The Harrington Discovery Institute at University Hospitals in Cleveland, OH—part of The Harrington Project for Discovery & Development—aims to advance medicine and society by enabling our nation’s most inventive scientists to turn their discoveries into medicines that improve human health. The institute was created in 2012 with a $50 million founding gift from the Harrington family and instantiates the commitment they share with University Hospitals to a Vision for a ‘Better World’. For more information, visit: HarringtonDiscovery.org.
About Fund for Cures UK, Ltd.
University Hospitals Health System, Inc. of Cleveland, Ohio, USA established Fund for Cures UK, Ltd. (Fund for Cures UK) in 2020 as an independent, registered charity to utilize the Harrington Discovery Institute model to advance promising scientific discoveries into medicines. Fund for Cures UK makes charitable grants to leading UK universities, medical schools, research institutes, and other charitable and scientific institutions, and obtains no rights or intellectual property that may be generated through the grant-funded research. For more information, visit: FundforCures.org.uk.
About Morgan Stanley GIFT Cures
Morgan Stanley GIFT Cures powered by Harrington Discovery Institute offers philanthropists the unique funding opportunity to bridge the gap in the valley of death and greatly impact the development of cures. By supporting the world’s most promising research, philanthropists can directly advance Harrington Discovery Institute’s portfolio of hundreds of breakthrough discoveries that are being de-risked and developed into novel therapies for patients suffering from chronic and rare diseases. For more information, visit: MSGIFTCures.donorgift.org.
