Why some kids get sicker: the hidden power of nose bacteria

Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in children under two years old, resulting in significant morbidity and a heavy economic burden on healthcare systems worldwide. Despite its widespread prevalence, the relationship between respiratory bacteria and RSV infection has remained underexplored. The interactions between viruses and the microbiome—especially in the early stages of infection—are critical, as they can influence immune responses and disease outcomes. However, studies have shown varying results regarding how specific bacterial profiles affect RSV severity, indicating the need for more comprehensive research to clarify these complex dynamics.

A new scoping review (DOI: 10.1002/pdi3.97), led by the Children’s Hospital of Chongqing Medical University and published in Pediatric Discovery on July 16, 2024, takes a deeper look at how respiratory bacteria influence RSV infection outcomes. The study synthesizes data from 33 studies, aiming to unravel how bacterial colonization in the respiratory tract impacts both the immediate severity of RSV infections and long-term respiratory health in children.

The review identifies several key bacterial species prevalent in the respiratory tracts of children with RSV infections, including Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus. These bacteria were found to have significant effects on both short-term and long-term RSV outcomes. Haemophilus influenzae, for example, was consistently associated with more severe disease, longer hospital stays, and higher rates of ICU admissions. In contrast, Streptococcus pneumoniae showed mixed results: while some studies linked it to more severe RSV infections, others suggested that higher bacterial densities might actually provide a protective effect, reducing the risk of severe disease. These findings highlight the complex and sometimes contradictory relationship between bacterial colonization and RSV infection outcomes. Long-term consequences of these bacterial profiles were also evident in the study, with certain bacteria influencing the development of recurrent wheezing or asthma. For instance, the presence of Lactobacillus was associated with a reduced risk of childhood wheezing, while higher levels of Moraxella catarrhalis and Streptococcus pneumoniae correlated with an increased risk of recurring wheezing episodes. These results emphasize the critical role of the respiratory microbiome in shaping both the acute and chronic phases of RSV infection, suggesting that modulating bacterial profiles could be an important therapeutic approach to mitigate disease severity and prevent long-term respiratory complications.

Dr. Yu Deng, the corresponding author of the study, stressed the complexity of the findings and the need for further research: “Our study underscores the pivotal role that respiratory microflora play in shaping RSV infection outcomes. However, the inconsistent findings also reflect the intricate nature of host-microbe interactions. More targeted research is essential to fully understand these dynamics and develop effective interventions.”

The implications of this research for pediatric healthcare are profound. By elucidating the impact of specific bacterial profiles on both the severity of RSV infections and their long-term health consequences, the study paves the way for potential new strategies in prevention and treatment. Interventions that modify the respiratory microbiome could help reduce the severity of RSV infections and potentially prevent the development of chronic conditions like asthma. Moving forward, continued research into the mechanisms behind these microbial interactions holds the promise of microbiome-based therapies that could transform the management of RSV and other respiratory diseases in children.

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References

DOI

10.1002/pdi3.97

Original Source URL

https://doi.org/10.1002/pdi3.97

Funding information

This study was supported by Natural Science Foundation of Chongqing, China (cstc2019jcyj-msxmX0858); Returned Overseas Students Entrepreneurship Innovation Support Program (cx2019068); Scientific and Technological Research Program of Chongqing Municipal Education Commission (KJQN202000431); Chongqing Science and Health Joint Medical Research Project (2020FYYX086); Program for Youth Innovation in Future Medicine; CQMU Program for Youth Innovation in Future Medicine; and National Key Research and Development Program of China (2022YFC2704900).

About Pediatric Discovery

Pediatric Discovery is a Gold Open Access publication and officially sponsored by The National Clinical Research Center for Child Health and Disorders of China, and Children’s Hospital of Chongqing Medical University. The journal does not charge any submission fees. The Article Publication Charge (APC) is currently waived for accepted manuscripts. Pediatric Discovery is an open access and peer-reviewed international journal. The journal aims to advance the health and well-being of infants, children, and adolescents by disseminating cutting-edge discovery and knowledge in the field. It provides a platform for publishing and discussing the most important and state-of-the-art basic, translational and clinical discoveries affecting child and adolescent health and disorders in all aspects of pediatric medicine. Directory of Open Access Journals (DOAJ).