Weizmann Scientists Devise New Algorithm that Predicts Gestational Diabetes

A new computer algorithm enables prediction, in the early stages of pregnancy or even before pregnancy has occurred, of which women are at a high risk of gestational diabetes. Conducted by researchers at the Weizmann Institute of Science, the study was reported in Nature Medicine. The scientists analyzed data on nearly 600,000 pregnancies available from Israel’s largest health organization, Clalit Health Services. It may be possible, based on these predictions, to prevent gestational diabetes using nutritional and lifestyle changes.

“Our ultimate goal has been to help the health system take measures so as to prevent diabetes from occurring in pregnancy,” says senior author Prof. Eran Segal of the Department of Computer Science and Applied Mathematics and the Department of Molecular Cell Biology.

Gestational diabetes is characterized by high blood sugar levels that develop during pregnancy in women who did not previously have diabetes. It occurs in 3–9% of all pregnancies and is fraught with risks for both mother and baby. Typically, gestational diabetes is diagnosed between the 24^th and 28^th weeks of pregnancy, with the help of a glucose tolerance test in which the woman drinks a glucose solution and then undergoes a blood test to see how quickly the glucose is cleared from her blood.

In the new study, Prof. Segal and colleagues started out by applying a machine learning method to Clalit’s health records on some 450,000 pregnancies in women who gave birth between 2010 and 2017. Gestational diabetes had been diagnosed by glucose tolerance testing in about 4% of these pregnancies. After processing the “big data” – an enormous dataset made up of more than 2,000 parameters for each pregnancy, including the woman’s blood test results and her and her family’s medical histories – the algorithm revealed that nine of the 2,000-plus parameters were sufficient to accurately identify the women with high risk of developing gestational diabetes. The nine parameters included the woman’s age, body mass index, family history of diabetes, and results of her glucose tests during previous pregnancies (if any).

Next, to make sure that the nine parameters could indeed accurately predict the risk of gestational diabetes, the researchers applied them to Clalit’s health records on about 140,000 pregnancies that had not been part of the initial analysis. The results validated the study’s findings: the nine parameters helped accurately identify the women who ultimately developed gestational diabetes.

These findings suggest that by having a woman answer just nine questions, it should be possible to tell in advance whether she is at a high risk of developing gestational diabetes. And if this information is available early on – in the early stages of pregnancy or even before the woman has gotten pregnant – it could be possible to reduce her risk of diabetes through lifestyle measures such as exercise and diet. On the other hand, women identified by the questionnaire as being at a low risk of gestational diabetes may be spared the cost and inconvenience of the glucose testing.

Click here to access the self-assessment questionnaire for gestational diabetes.

In more general terms, this study has demonstrated the usefulness of large human-based datasets – and, specifically, electronic health records – for deriving personalized disease predictions that can lead to preventive and therapeutic measures.

The work was led by graduate students Nitzan Shalom Artzi, Dr. Smadar Shilo, and Hagai Rossman in Prof. Eran Segal’s lab at the Weizmann Institute of Science, in collaboration with Prof. Eran Hadar, Dr. Shiri Barbash-Hazan, Prof. Avi Ben-Haroush, and Prof. Arnon Wiznitzer of the Rabin Medical Center in Petah Tikva and Prof. Ran D. Balicer and Dr. Becca Feldman of Clalit Health Services.

Prof. Eran Segal is head of the Crown Human Genome Center at the Weizmann Institute of Science. His research is supported by the Larson Charitable Foundation New Scientist Fund; the Else Kroener Fresenius Foundation; the Adelis Foundation; Ms. Judith Benattar; Ms. Aliza Moussaieff; the Fannie Sherr Fund; the Estate of Zvia Zeroni; and the European Research Council.

The Weizmann Institute of Science in Rehovot, Israel, is one of the world’s top-ranking multidisciplinary research institutions. The Institute’s 3,800-strong scientific community engages in research addressing crucial problems in medicine and health, energy, technology, agriculture, and the environment. Outstanding young scientists from around the world pursue advanced degrees at the Weizmann Institute’s Feinberg Graduate School. The discoveries and theories of Weizmann Institute scientists have had a major impact on the wider scientific community, as well as on the quality of life of millions of people worldwide.

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