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Composition of Joint Lubricant Potential Culprit Behind Osteoarthritis

April 11, 2023 sarah JonasResearch Results

The exact mechanism of cartilage breakdown in osteoarthritis is unknown, but damage from mechanical stress with insufficient self-repair is believed to be the main culprit. The composition of synovial fluid, or joint lubricant, changes significantly: The concentration and molecular weight of hyaluronic acid tends to decrease. In Biointerphases, researchers explore the disease-driven breakdown of hyaluronan and the mechanistic implications of these changes on the lubrication and subsequent wear of joints.

Case Western Reserve University-led research uncovers connections between psoriasis and joint disease

June 8, 2020 sarah JonasResearch Results

A team led by Case Western Reserve University School of Medicine researchers has made two major discoveries involving psoriasis, a chronic and debilitating skin disease with no known cure.