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Researchers at Children’s Hospital of Philadelphia Reveal New Insights into Non-Inflammatory Causes of Rare Neurological Symptoms in Children, Adolescents and Young Adults Following CAR-T Therapy

October 7, 2024 sarah JonasResearch Results

Researchers at Children’s Hospital of Philadelphia (CHOP) revealed for the first time that children, adolescents and young adults may experience very rare neurological issues of paraparesis and quadriparesis following chimeric antigen receptor T-cell (CAR-T) therapy, a type of immunotherapy used to treat B-cell Acute Lymphoblastic Leukemia (B-ALL).

Uso de tesoura molecular para aprimorar a terapia com células CAR-T

September 26, 2024 sarah JonasResearch Results

Pesquisadores da Mayo Clinic investigaram as bases moleculares do câncer e descobriram uma nova razão pela qual o receptor de antígeno quimérico (terapia com células CAR-T) não funciona em alguns pacientes. Essa descoberta estimulou novas estratégias que incorporam anticorpos e edição genética para melhorar os resultados desse tratamento inovador para os pacientes. Esta pesquisa do Dr. Saad Kenderian, consultor em hematologia da Mayo Clinic, foi publicada na Nature Communications.