A Head Start on the Next Pandemic

Investigating viruses with spillover potential could give us a head start on the next pandemic and minimize its severity; one such virus is RshTT200, discovered in Cambodian bats in 2010. During ACA’s 73rd annual meeting, July 7-11, Samantha Zepeda from the University of Washington will present her team’s investigation into RshTT200. The team used cryo-electron microscopy to solve the spike protein structure. Once the spike proteins were understood, they built harmless, nonreplicating pseudoviruses expressing the spike proteins to investigate how RshTT200 accesses human cells.