Stromal vascular fraction: Mechanisms and application in reproductive disorders

Stromal vascular fraction (SVF) is a complex mixture derived from adipose tissue, consisting of a variety of cells. Due to its potential for tissue repair, immunomodulation, and support of angiogenesis, SVF represents a promising frontier in regenerative medicine and offers potential therapy for a range of disease conditions. In this article, we delve into the mechanisms through which SVF exerts its effects and explore its potential applications in treating both male and female reproductive disorders, including erectile dysfunction, testicular injury, stress urinary incontinence and intrauterine adhesion.

Key Words: Stromal vascular fraction; Angiogenesis; Inflammation; Regenerative medicine; Reproductive disorders

Core Tip: This article will analyze the minireview by Jeyaraman et al, with a focus on the future direction of stromal vascular fraction (SVF) for reproductive therapy. SVF received increasing attention for its multi-faceted function including immunomodulation, pro-angiogenesis and tissue repair. By reviewing the current research in the field of erectile dysfunction, testicular injury, intrauterine adhesion, and stress urinary incontinence, we highlight the opportunities of SVF in treating reproductive disorders and improving infertility. With advancements in standardizing protocol of SVF isolation and more clinical trials exploring its efficacy and safety, SVF should be promoted for more applications in practice.

• Citation: Liu ZH, Xie QQ, Huang JL. Stromal vascular fraction: Mechanisms and application in reproductive disorders. World J Stem Cells 2025; 17(1): 101097
• URL: https://www.wjgnet.com/1948-0210/full/v17/i1/101097.htm
• DOI: https://dx.doi.org/10.4252/wjsc.v17.i1.101097