Kang Chen, Ph.D., associate professor of obstetrics and gynecology will use the grant, “Mechanism and function of transplacental IgD,” to tackle early infant morbidity due to increasing incidences of food allergies.
IgD is an antibody isotype present in the blood and tissue fluids, including human respiratory mucosa. Chen discovered that IgD is important in respiratory immune defense by inhibiting mucosal adhesion of pathogens and activating antimicrobial and immune-amplifying functions of basophils. IgD activation of basophils also suppresses Immunoglobulin E (IgE)-induced allergic functions, and increased food allergen-specific IgD production correlates with protection against food allergy after oral immunotherapy in children. Maternal tetanus, diphtheria, and acellular pertussis (TDaP) vaccine and food exposure in pregnancy induces the production of vaccine- and food-specific IgD, which is transferred across the placenta to the fetus in humans and mice.
Food allergies are a major cause of neonatal morbidity. Food allergies also significantly affect young infants; they can be serious or fatal, and are associated with long-term morbidity, imposing heavy social and economic burdens. Unfortunately, no effective treatment is currently available for neonatial food allergies, except avoiding or replacing the offending food, which is often impossible due to the ubiquitous nature of some food components.
“This project, funded by the National Institutes of Health, will allow our research team to elucidate the mechanisms of the placental transfer of IgD and determine if maternal IgD promotes neonatal immune protection against food allergy,” said Chen. “Our studies have shown that maternal IgD specific to vaccines or food acts as a specific and prophylactic fetal immune education cue to protect neonates against food allergy. Our research will have a major impact on our understanding of the origin of allergies in newborns and children.”
Chen’s study is expected to reveal the unique functions of maternal IgD — an ancient yet still mysterious antibody — in neonatal immune function that maternal Immunoglobulin G (IgG) does not have, and aims to have a profound impact on improving neonatal health by directing the design of IgD-targeting maternal vaccines or adoptive immunotherapies.
The project number for this NIH award is R01-AI-163045-01.
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