Metronomic chemotherapy: a promising approach for pediatric neuroblastoma

Neuroblastoma is the most common extracranial solid tumor in children, with nearly 50% of cases diagnosed at an advanced stage, often with metastatic disease. Despite advances in treatment, survival rates for high-risk and relapsed/refractory neuroblastoma remain dismal, and options like autologous stem cell transplantation and immunotherapy are frequently unavailable in low- and middle-income countries. Given these stark realities, there is a critical need for alternative, more accessible therapies like metronomic chemotherapy (MC) to improve survival prospects for these children.

On December 10, 2024, a team of researchers from the Children’s Hospital of Chongqing Medical University published a comprehensive review (DOI: 10.1002/pdi3.2512) in Pediatric Discovery, detailing the potential of MC in treating pediatric neuroblastoma. The study provides an in-depth examination of MC’s efficacy, safety, and its potential role as a maintenance therapy and in relapsed/refractory settings, offering new hope for children in desperate need of effective treatments.

The review delves into the mechanics of MC as a therapeutic strategy, emphasizing its ability to maintain sustained drug levels over extended periods with reduced toxicity. Unlike conventional high-dose chemotherapy regimens, MC uses low-dose agents like cyclophosphamide and etoposide, often in combination with non-chemotherapeutic agents such as celecoxib and thalidomide. Early studies have reported promising results, with disease control rates reaching up to 45%, particularly in high-risk patients. One of MC’s most remarkable features is its efficacy in resource-limited regions, where access to advanced treatments such as autologous stem cell transplantation or immunotherapy is often unavailable. The review also highlights a growing trend in combining MC with immunotherapy and targeted treatments like nivolumab and pazopanib to enhance its therapeutic effects. However, despite these encouraging findings, variability in drug combinations, dosages, and treatment schedules across studies has hindered the establishment of standardized protocols. Identifying predictive biomarkers and optimizing treatment regimens remain essential to unlocking MC’s full potential.

The authors underscores the importance of continued research to fine-tune MC protocols. “While MC has shown significant promise in improving survival and quality of life for pediatric neuroblastoma patients, further studies are necessary to identify the most effective drug combinations and biomarkers that predict response to treatment,” the authors noted. They call for further investigation into MC’s optimization reflects the need for a deeper understanding of how this innovative treatment can best serve young patients.

The application of MC in pediatric neuroblastoma holds immense promise, especially in resource-limited regions where access to advanced therapies is restricted. MC’s low toxicity profile, ease of outpatient administration, and cost-effectiveness position it as a highly attractive alternative to traditional high-intensity treatments. As a maintenance therapy and in palliative care, it offers new hope for improved outcomes. By integrating MC with emerging immunotherapies and targeted treatments, there is an opportunity to further enhance its effectiveness. Moving forward, the development of standardized protocols and the identification of biomarkers to guide personalized treatment strategies will be crucial to optimizing MC’s impact, making it a cornerstone in both newly diagnosed and relapsed/refractory neuroblastoma management worldwide.

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References

DOI

10.1002/pdi3.2512

Original Source URL

https://doi.org/10.1002/pdi3.2512

About Pediatric Discovery

Pediatric Discovery is a Gold Open Access publication and officially sponsored by The National Clinical Research Center for Child Health and Disorders of China, and Children’s Hospital of Chongqing Medical University. The journal does not charge any submission fees. The Article Publication Charge (APC) is currently waived for accepted manuscripts. Pediatric Discovery is an open access and peer-reviewed international journal. The journal aims to advance the health and well-being of infants, children, and adolescents by disseminating cutting-edge discovery and knowledge in the field. It provides a platform for publishing and discussing the most important and state-of-the-art basic, translational and clinical discoveries affecting child and adolescent health and disorders in all aspects of pediatric medicine. Directory of Open Access Journals (DOAJ).