Gene Expression and Bioinformatics Tools to Optimize Cancer Therapy

In the field of biomedical research and genomics, the advancement of bioinformatics  technologies and tools is opening new frontiers in the understanding of diseases and their diagnosis and  treatment. In particular, differential gene expression analysis (DGE) is emerging as a crucial technique to  investigate the molecular mechanisms underlying diseases. 

The most significant results were collected and discussed in the review “Differential gene expression analysis  pipelines and bioinformatic tools for the identification of specific biomarkers: A review” by Diletta Rosati,  Maria Palmieri, Giulia Brunelli, Andrea Morrione, Francesco Iannelli, Elisa Frullanti and Antonio Giordano.  This comprehensive review is the result of a joint effort between the teams of Prof. Antonio Giordano and  Prof. Elisa Frullanti, within the Med Biotech Hub and Competence Center, Department of Medical  Biotechnologies, University of Siena and the Sbarro Health Research Organization together with the Sbarro  Institute for Molecular Medicine and Cancer Research at Temple University in Philadelphia. The review was  published in March 2024 in the prestigious journal Computational and Structural Biotechnology Journal. 

The review explores the analysis of differential gene expression, focusing on the identification of specific  biomarkers for advances in precision medicine. It aggregates and analyzes findings from relevant studies in  the field, offering a holistic view of recent developments and their potential impact on disease treatment. The article discusses the challenges and opportunities in this field, emphasizing the importance of such  methodologies for the future of biomedical research. With its comprehensive approach, it serves as a  valuable resource for anyone interested in advances in genetic analysis techniques and their practical  application in healthcare.  

“Differential gene expression analysis pipelines and bioinformatic tools for the identification of specific biomarkers: A review” 

by Diletta Rosati, Maria Palmieri, Giulia Brunelli, Andrea Morrione, Francesco Iannelli, Elisa Frullanti and  Antonio Giordano. 

Computational and Structural Biotechnology Journal 2024 https://doi.org/10.1016/j.csbj.2024.02.018

About the Sbarro Health Research Organization

The Sbarro Health Research Organization (SHRO) is non-profit charity committed to funding excellence in basic genetic research to cure and diagnose cancer, cardiovascular diseases, diabetes and other chronic illnesses and to foster the training of young doctors in a spirit of professionalism and humanism. To learn more about the SHRO please visit www.shro.org.