Kidney Clock Gene Plays Role in Regulating Blood Pressure in Male Mice

Article title: Loss of circadian gene Bmal1 in the collecting duct lowers blood pressure in male, but not female, mice

Authors: Dingguo Zhang, Chunhua Jin, Ijeoma E. Obi, Megan K. Rhoads, Reham H. Soliman, Randee S. Sedaka, John Miller Allan, Binli Tao, Joshua S. Speed, Jennifer S. Pollock, David M. Pollock

From the authors: “Overall, our study showed the sex-dependent regulation of [blood pressure] by collecting duct Bmal1, which aids our understanding of the connection between circadian misalignment and cardiovascular health. While Bmal1 is considered a core clock gene, the characteristic circadian pattern of [blood pressure] remained intact despite there being a lower overall [blood pressure] throughout the day.”

This study is highlighted as one of March’s “best of the best” as part of the American Physiological Society’s APSselect program.

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