Key Words: Stem cells; Advanced therapy medicinal products; Tissue-engineered products; Health; Three-dimensional cell culture
Core Tip: Stem cells play a crucial role in tissue engineering by offering the potential for regenerating of damaged tissues, which is critical for developing advanced therapy medicinal products. Stem cells can differentiate into specific cell types and promote tissue repair through various mechanisms. When combined with tissue engineering techniques, stem cell therapy enhances cell viability, differentiation, and therapeutic efficacy, overcoming disease treatment limitations. However, translating stem cell research into approved clinical therapies has been challenging. Regulatory bodies have provided guidelines to ensure the safety and efficacy of advanced therapy medicinal products utilizing stem cells before the approval for clinical use.
- Citation: Granjeiro JM, Borchio PGM, Ribeiro IPB, Paiva KBS. Bioengineering breakthroughs: The impact of stem cell models on advanced therapy medicinal product development. World J Stem Cells 2024; 16(10): 860-872
- URL: https://www.wjgnet.com/1948-0210/full/v16/i10/860.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v16.i10.860