A synopsis of new clinical guidelines from the U.S. Department of Veterans Affairs (VA) and the Department of Defense (DoD) details 34 recommendations for treating posttraumatic stress disorder (PTSD) and co-occurring conditions. The VA/DoD guidelines notably recommend the use of specific manualized psychotherapies over pharmacotherapy and recommend against the use of benzodiazepines, cannabis, or cannabis-derived products. The synopsis is published in Annals of Internal Medicine.