Researchers Use Two-photon Microscopy, Optical Coherence Tomography to View Age-related Blood-brain Barrier Changes

Article title: Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by two-photon microscopy and optical coherence tomography

Authors: Ádám Nyúl-Tóth, Stefano Tarantini, Jordan Delfavero, Feng Yan, Priya Balasubramanian, Andriy Yabluchanskiy, Chetan Ahire, Tamas Kiss, Tamas Csipo, Agnes Lipecz, Attila E Farkas, Imola Wilhelm, István A Krizbai, Qinggong Tang, Anna Csiszar, Zoltan I Ungvari

From the authors: “Methods for longitudinal detection of age-related increases in blood-brain barrier permeability and microvascular rarefaction in the mouse cerebral cortex by intravital two-photon microscopy and optical coherence tomography are presented.” 

This study is highlighted as one of April’s “best of the best” as part of the American Physiological Society’s APSselect program.